1,051 research outputs found

    Urban Public Transportation Planning with Endogenous Passenger Demand

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    An effective and efficient public transportation system is crucial to people\u27s mobility, economic production, and social activities. The Operations Research community has been studying transit system optimization for the past decades. With disruptions from the private sector, especially the parking operators, ride-sharing platforms, and micro-mobility services, new challenges and opportunities have emerged. This thesis contributes to investigating the interaction of the public transportation systems with significant private sector players considering endogenous passenger choice. To be more specific, this thesis aims to optimize public transportation systems considering the interaction with parking operators, competition and collaboration from ride-sharing platforms and micro-mobility platforms. Optimization models, algorithms and heuristic solution approaches are developed to design the transportation systems. Parking operator plays an important role in determining the passenger travel mode. The capacity and pricing decisions of parking and transit operators are investigated under a game-theoretic framework. A mixed-integer non-linear programming (MINLP) model is formulated to simulate the player\u27s strategy to maximize profits considering endogenous passenger mode choice. A three-step solution heuristic is developed to solve the large-scale MINLP problem. With emerging transportation modes like ride-sharing services and micro-mobility platforms, this thesis aims to co-optimize the integrated transportation system. To improve the mobility for residents in the transit desert regions, we co-optimize the public transit and ride-sharing services to provide a more environment-friendly and equitable system. Similarly, we design an integrated system of public transit and micro-mobility services to provide a more sustainable transportation system in the post-pandemic world

    Dynamic scaling for the growth of non-equilibrium fluctuations during thermophoretic diffusion in microgravity

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    Diffusion processes are widespread in biological and chemical systems, where they play a fundamental role in the exchange of substances at the cellular level and in determining the rate of chemical reactions. Recently, the classical picture that portrays diffusion as random uncorrelated motion of molecules has been revised, when it was shown that giant non-equilibrium fluctuations develop during diffusion processes. Under microgravity conditions and at steady-state, non-equilibrium fluctuations exhibit scale invariance and their size is only limited by the boundaries of the system. In this work, we investigate the onset of non-equilibrium concentration fluctuations induced by thermophoretic diffusion in microgravity, a regime not accessible to analytical calculations but of great relevance for the understanding of several natural and technological processes. A combination of state of the art simulations and experiments allows us to attain a fully quantitative description of the development of fluctuations during transient diffusion in microgravity. Both experiments and simulations show that during the onset the fluctuations exhibit scale invariance at large wave vectors. In a broader range of wave vectors simulations predict a spinodal-like growth of fluctuations, where the amplitude and length-scale of the dominant mode are determined by the thickness of the diffuse layer.Comment: To appear in Scientific Report

    THREE ESSAYS ON IMPLEMENTATION THEORY

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    Ph.DDOCTOR OF PHILOSOPH

    STATISTICAL METHODS FOR RECURRENT MARKER PROCESS IN THE PRESENCE OF TERMINAL EVENTS

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    Benefit-risk assessment is a crucial step in the medical decision process. In many biomedical studies, both longitudinal marker measurements and time to a terminal event serve as important endpoints for benefit-risk assessment. The effect of an intervention or a treatment on the longitudinal marker process, however, can be in conflict with its effect on the time to the terminal event. Thus questions arise on how to evaluate treatment effects based on the two endpoints, for the purpose of deciding on which treatment is most likely to benefit the patients. In this dissertation, we present a unified framework for benefit-risk assessment using the observed longitudinal markers and time to event data. We propose a cumulative weighted marker process to synthesize information from the two endpoints, and use its mean function at a pre-specified time point as a benefit-risk summary measure. We consider nonparametric estimation of the summary measure under two scenarios: (i) the longitudinal marker is measured intermittently during the study period, and (ii) the value of the longitudinal marker is observed throughout the entire follow-up period. The large-sample properties of the estimators are derived and compared. Simulation studies and the application to an AIDS clinical trial exhibit that the proposed methods are easy to implement and reliable for practical use. In many follow-up or surveillance studies, marker data are collected conditioning on the occurrence of recurrent events. In contrast with the above situation that the marker measurements exists at any time before the terminal event, sometimes marker measurements are triggered by the occurrence of recurrent events. Examples include the medical cost for inpatient or outpatient cares, length-of-stay for hospitalizations, and prognostic or quality-of-life measurement repeatedly measured at multiple infections related to a certain disease. A recurrent marker process, defined between a pre-specified time origin and a terminal event, is composed of recurrent events and repeatedly measured marker measurements. We consider nonparametric estimation of the mean recurrent marker process in the situation when the occurrence of terminal event is subject to competing risks. Statistical methods and inference are developed to address a variety of questions and applications, for the purposes of estimating and comparing the integrated risk in relation to recurrent events, marker measurements and time to the terminal event for different competing risk groups. A SEER-Medicare linked database is used to illustrate the proposed approaches

    Slowing-down of non-equilibrium concentration fluctuations in confinement

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    Fluctuations in a fluid are strongly affected by the presence of a macroscopic gradient making them long-ranged and enhancing their amplitude. While small-scale fluctuations exhibit diffusive lifetimes, larger-scale fluctuations live shorter because of gravity, as theoretically and experimentally well-known. We explore here fluctuations of even larger size, comparable to the extent of the system in the direction of the gradient, and find experimental evidence of a dramatic slowing-down in their dynamics. We recover diffusive behaviour for these strongly-confined fluctuations, but with a diffusion coefficient that depends on the solutal Rayleigh number. Results from dynamic shadowgraph experiments are complemented by theoretical calculations and numerical simulations based on fluctuating hydrodynamics, and excellent agreement is found. The study of the dynamics of non-equilibrium fluctuations allows to probe and measure the competition of physical processes such as diffusion, buoyancy and confinement.Comment: Includes see Supplementary Material. Submitted to PR
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